Mingyun Bae, PhD

Mingyun joined the lab in September 2023 as a postdoctoral fellow. He received his B.S. in Biochemistry from Yonsei University and his M.S. and Ph.D. in computational biology from KAIST (Korea Advanced Institute of Science and Technology). His M.S. research in Jungkyoon Choi's lab focused on understanding the epigenomic changes in cancer and the interpretation of noncoding variants based on 3D chromatin structure. During his Ph.D. studies, he studied cell-free DNA to detect early-stage cancer and predict its tissue of origin. To sensitively detect cancer, he developed deep learning models that utilize the distribution pattern of somatic mutations, fragment size information, and fragment depth at tissue-specific nucleosome-depleted regions. His primary research interest in the Lee lab is to investigate the accumulation of mosaic variants across human aging and to track clonal evolution using mosaic variants as endogenous barcodes.