Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

Citation:

Rodriguez-Martin B , Alvarez EG , Baez-Ortega A , .., Lee EA, .., Campbell PJ**, Tubio JMC**, PCAWG Structural Variation WG, ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Net. Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours [Internet]. Nature Genetics In Press;

Abstract:

About half of all cancers have somatic integrations of retrotransposons. To characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,774 cancer genomes from 37 histological cancer subtypes. We identified 20,230 somatically acquired retrotransposition events, affecting 43% of samples, and spanning a range of event types. L1 insertions emerged as the third most frequent type of somatic structural variation in cancer. Aberrant L1 integrations can delete megabase-scale regions of a chromosome, sometimes removing tumour suppressor genes, as well as inducing complex translocations and large-scale duplications. Somatic retrotranspositions can also initiate breakage-fusion-bridge cycles of genomic instability, leading to high-level amplification of oncogenes. These observations illuminate a relevant role of L1 retrotransposition in remodeling the cancer genome, with potential implications in the initiation and/or development of human tumours.

bioRxiv

Last updated on 09/20/2018